Cisplatin is a widely used chemotherapeutic agent with a high degree of ototoxicity and an average incidence of over 60% (Karasawa and Steyger, 2015). Ototoxicity depends on several factors, including patient age, cumulative dose of cisplatin, and genetic susceptibility (Landier, 2016; Lanvers-Kaminsky and … See more Mechanisms that may underlie cisplatin-induced ototoxicity include excessive ROS, inflammation, cellular uptake of cisplatin, and autophagy, which result in cell death. Preclinical … See more he mechanistic basis for ototoxicity induced by cisplatin is not fully understood. However, cisplatin is known to damage the organ of … See more Although an extensive number of preclinical studies have explored protective interventions to reduce cisplatin-induced ototoxicity, … See more In recent decades, preclinical pharmacological strategies have assessed means by which to reduce the ototoxic effects of cisplatin. However, none have been approved by the FDA. These assessments have … See more WebCisplatin can cause ringing in the ear and hearing loss, but it can resolve with time. I agree with the others who have written that it's vitally important to report every symptom to the …
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WebSep 4, 2024 · Cisplatin is a powerful drug used in some chemotherapy treatments to treat many forms of cancer. Cisplatin and similar platinum-based drugs are prescribed for an … WebApr 13, 2024 · Cisplatin therapy is used in a variety of treatment protocols, but it is most commonly used in gynecological (ovarian and cervical) and head and neck cancers. In … cinnamon moonshine for sale
Cisplatin-Induced Ototoxicity: A Concise Review of the Burden ...
WebFeb 9, 2024 · I began experiencing hearing loss and tinnitus approx. one month after receiving my first dose of Cisplatin during chemotherapy. I was diagnosed with Hodgkin's Lymphoma at 17 years old and have been in remission since 2008. My hearing loss has been gradually declining over the years. I received my first cochlear implant in 2015 and … WebApr 18, 2016 · Glad to hear your tinnitus is getting better. I have numbness in my feet that gets better the weeks I am off cisplatin and just on vinorelbine. There's no pain though. It's just a weird feeling to walk around with really numb feet. Then it slowly gets better till it is time for cisplatin again... Denzi, sorry to hear you still have tinnitus. WebTinnitus is often the first sign of damage caused by chemotherapy. You might also lose hearing when the drug damages the inner ear cells. These hearing problems usually happen in both ears. Hearing loss from … diagram of cow heart