WebDec 31, 2024 · Flow cytometry data showed that IRF4 CKO had significantly more leukocytes, including total peripheral myeloid cells (pMyeloid), monocytes, and neutrophils, infiltrating into the stroke brain compared to the control group ( Fig. 5 A – D ). WebJ Exp Med (2013) 210 (13): 2887–2902. The transcription factor interferon regulatory …
Transcription factor IRF4 controls plasma cell differentiation and ...
WebIRF4: A gene on chromosome 6p25-p23 that encodes a member of the interferon … WebMay 27, 2024 · IRF4 protein quantification may provide a valuable prognostic tool to predict disease severity and sensitivity to IRF4-targeted therapies. This flow-cytometry-based procedure could also be rapidly translated into a clinically compatible assay. For complete details on the use and execution of this protocol, please refer to Mondala et al. (2024). how to start exercising when overweight
IRF4 Activity Is Required in Established Plasma Cells to Regulate …
WebApr 15, 2024 · In T cells, IRF4 controls expression of a large number of genes, including genes coding for T cell effector proteins, for enzymes in central metabolism pathways, and for transcription factors and regulatory … WebApr 9, 2024 · Flow cytometry was used to identify the proportion of pro-inflammatory CD86 + CD206-and HL associated anti-inflammatory CD163 + CD206 ... (weak expression), and IRF4/MUM1. Surface B-cell markers such as CD20 and CD79a are often negative, although CD20 may be more variably expressed in practice due to improved antigen retrieval … WebTel +86 13607141618. Email [email protected]. Background: Therapeutic hypothermia (TH) has been proven to be protective in ischemic stroke (IS) due to its anti-inflammatory capacity. Recently, the interferon regulatory factor 4 (IRF4) has been characterized as a central regulator of neuroinflammation in IS. how to start exercise routine