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Topoisomerase 2a

WebFeb 27, 2024 · The type 2 DNA topoisomerases (Top2) are conserved enzymes and biomarkers for cell proliferation. The catalytic activities of the human isoform Top2a are essential for the regulation of DNA ... WebTopoisomerase II Alpha has been identified by DNA microarray and transcriptional profiling as a gene that is overexpressed in Cervical Carcinomas. The TOP2A gene is approximately 30 kb in size and encodes …

BAZ2A-RNA mediated association with TOP2A and KDM1A …

WebNov 15, 2011 · The HER2 amplicon on chromosome 17q is variable in size and occasionally includes Topoisomerase 2A (TOP2A) at 17q21-22. It has been suggested that TOP2 co-amplification, not HER2 amplification on … WebMay 3, 2024 · Topoisomerase 2a (Topo2a)-dependent G 2 arrest engenders faithful segregation of sister chromatids, yet in certain tumor cell lines where this arrest is dysfunctional, a PKCε-dependent failsafe pathway can be triggered. Here we elaborate on recent advances in understanding the underlying mechanisms associated with this G 2 … new hope nm https://illuminateyourlife.org

Type II topoisomerase - Wikipedia

WebApplications. Use a concentration of 0.5 - 1 µg/ml. Predicted molecular weight: 174 kDa. Use a concentration of 0.5 - 1 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. (Primary incubation for 30 min at RT). Use at an assay dependent concentration. WebFeb 28, 2024 · Topoisomerases have essential roles in transcription, DNA replication, chromatin remodelling and, as recently revealed, 3D genome organization. ... (Fig. 2a) may account for its role in activating ... WebSep 1, 2024 · However, recent studies have suggested that the topoisomerase 2a isozyme is predominantly responsible for the carcinogenic side effects associated with etoposide and doxorubicin chemotherapy. Thus, we need to find a promising topoisomerase 2-targeting anticancer agent that avoids these carcinogenic side effects. Recent studies have found … in the flavian period was renowned

Human topoisomerases and their roles in genome stability and

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Topoisomerase 2a

TOP2A - Wikipedia

WebZone 2A = 0.15g D Zone 28 = 0.20g D Zone 3 = 0.30g II Zone 4 = 0.40g Source: 1997 Edition UBC NRC-070 Submitted: 5/8/2015-1-Kaua'l .SeattIe OlymÞia washing ton Portland Salem … WebTopoisomerase II Alpha has been identified by DNA microarray and transcriptional profiling as a gene that is overexpressed in Cervical Carcinomas. The TOP2A gene is approximately 30 kb in size and encodes a 170 kDa protein. Topoisomerase II Alpha antibody is expressed in proliferating cells and in numerous human malignant tumors, including colon, gastric …

Topoisomerase 2a

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WebSep 1, 2024 · However, recent studies have suggested that the topoisomerase 2a isozyme is predominantly responsible for the carcinogenic side effects associated with etoposide … WebJun 4, 2024 · In silico screening of the interactions with the target proteins tubulin, human topoisomerase II β and human ROCK1 via docking calculation permitted the selection of the new molecules 1a–c, 2a–c and 3 . Their drug-likeness was computationally predicted regarding the physico-chemical properties relevant for the development of a drug.

WebSpecifically, the interaction of NELFA with DNA topoisomerase 2a (Top2a) is essential for NELFA to activate Dux; Dux will be silenced in Top2a-deficient cells even when NELFA is overexpressed . The role of NELFA remains controversial, as other studies indicate that NELFA is a direct target of DUX rather than a driver of Dux . More data from ... WebSep 30, 2012 · Type IIA topoisomerases (topos) control supercoiling and disentangle chromosomes by an ATP-dependent strand-passage mechanism. The structure of a full …

• Watt PM, Hickson ID (November 1994). "Structure and function of type II DNA topoisomerases". The Biochemical Journal. 303 (Pt 3): 681–695. doi:10.1042/bj3030681. PMC 1137600. PMID 7980433. • Bronner C, Hopfner R, Mousli M (2002). "Transcriptional regulation of the human topoisomerase IIalpha gene". Anticancer Research. 22 (2A): 605–612. PMID 12014628. WebApr 7, 2015 · This study aims to investigate clinical significance of topoisomerase 2A (TOP2A) expression and TOP2A gene change in operable invasive breast cancer. This is a retrospective analysis, which ...

WebDNA gyrase is a type II topoisomerase that introduces or removes negative supercoils, forms or resolves catenanes, and knots or unknots DNA ( Gellert et al., 1976; Kreuzer and …

WebJan 10, 2024 · Topoisomerase I (TOP1) relaxes both positive and negative supercoils by nicking DNA and after rotation of the broken DNA strand closes the nick. Here, the authors present the DNA free crystal ... in the flat field vinylWebThe type 2 DNA topoisomerases (Top2) are evolutionary conserved enzymes and biomarkers for cell proliferation [ 1]. They are involved in essential cellular processes such as DNA replication, DNA transcription, … new hope north dakotaWebMar 27, 2024 · Topoisomerase II alpha (TOP2A) protein has been shown to be a proliferation marker associated with tumor grade and Ki67 index. ... [16, 28], thus could probably explain the poor correlation between TOP 2A protein expression and gene amplification. Since TOP2A protein represents the ultimate expression of TOP2A as well as tumor cell ... in the flatWebHome; About. Mission Statement / Core Values; History; Membership Info; Schools. A – F; G – L; M – T; U – Z; Conferences; Classifications; Divisions; Regions ... new hope northeastnew hope norwichWebThis study aims to investigate clinical significance of topoisomerase 2A (TOP2A) expression and TOP2A gene change in operable invasive breast cancer. This is a … new hope nj things to doWebProteomic Analysis Reveals that Topoisomerase 2A is Associated with Defective Sperm Head Morphology. Topoisomerase II contributes to DNA secondary structure-mediated … new hope north fayetteville ga