WebAbstract. There is evidence that the susceptibility to the teratogenic effect of drugs within human populations varies extremely from one individual to another, even after identical exposures. One of the factors that may explain these interindividual differences is the genetic makeup in the pharmacokinetics and pharmacodynamics of the ... WebTeratogens. A teratogen is a substance that interferes with normal fetal development and causes congenital disabilities. Drugs, alcohol, chemicals and toxic substances are examples of teratogens. Teratogens can also increase the risk for miscarriage, preterm labor or …
Teratogen - Department of Obstetrics and Gynecology Faculty of …
WebTeratogenesis is a prenatal toxicity characterized by structural or functional defects in the developing embryo or fetus. It also includes intrauterine growth retardation, death of the embryo or fetus, and transplacental carcinogenesis (in which chemical exposure of the mother initiates cancer development in the…. WebTeratogens include general environmental factors, such as air pollution and radiation, but also the cigarettes, alcohol, and drugs that the mother may use. Teratogens do not always harm the fetus, but they are more likely to do so when they occur in larger amounts, for longer time periods, and during the more sensitive phases, as when the fetus is growing … otomoto bmw seria 4 2016
UpToDate
WebFeb 10, 2024 · About 140 drugs were known to have definite teratogenic effects, and another 65 were identified as having potential teratogenic effects. The proportion of pregnancies with exposure to definite teratogens decreased slightly over the 12-year study period from 1.9% to 1.2%, while exposures for potential teratogens increased from 3.4% to 5.3%. WebJan 14, 2024 · Some teratogens in pregnancy, such as thalidomide, cause serious developmental disorders if administered during the organogenetic period of certain parts (for example, limbs) of the embryo. Other teratogens in pregnancy cause mental and growth restrictions on embryos. Despite this, less than 2% of birth defects are caused by drugs … WebFeb 16, 2024 · Teratogens are factors that can alter normal intrauterine development of fetal growth, anatomic structures, physical functioning, and postnatal development. This definition encompasses environmental exposures, maternal medical disorders, infectious agents, and genetic conditions. Most discussions of teratogens usually center on drug … イェソン 子供